Mouse Mothers against decapentaplegic homolog 1 (Smad1) ELISA Kit

From Assay Genie, this Sandwich ELISA is designed for the quantitative measurement of mouse Mothers against decapentaplegic homolog 1 (SMAD1). It is intended for use with mouse serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids, and is for research use only.

The assay provides a detection range of 62.5-4000pg/mL and a sensitivity of 31.34pg/mL, with specificity for natural and recombinant mouse SMAD1 (UniProt P70340). Synonyms for the target include Dwarfin-A, Mothers-against-DPP-related 1, SMAD family member 1, Dwf-A, Mad-related protein 1, SMAD 1, MAD homolog 1, Madh1, and Madr1.

SMAD1 acts as a transcriptional modulator activated by BMP (bone morphogenetic protein) type 1 receptor kinase and is classified as a receptor-regulated SMAD (R-SMAD). It participates in BMP-mediated signalling, contributing to processes such as cell growth, differentiation, and apoptosis. Dysregulation of SMAD1 has been implicated in cancer, fibrosis, and developmental disorders, making the kit applicable to research into cancer progression, tissue regeneration, and developmental biology.