Mouse Mixed lineage kinase domain-like protein (Mlkl) ELISA Kit

A highly sensitive and specific sandwich ELISA from Assay Genie designed for the accurate detection of mouse Mixed lineage kinase domain-like protein (MLKL) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The assay uses a colorimetric detection method, is reactive with mouse samples, and is intended for research use only, supporting studies of cell death pathways, necroptosis, and inflammation. MLKL is a pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process implicated in various inflammatory and autoimmune diseases, and is activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane, and execution of programmed necrosis. The kit offers a detection range of 0.312-20ng/mL and a sensitivity of 0.18ng/mL, with specificity for natural and recombinant mouse MLKL (UniProt Q9D2Y4).