Mouse Methionine aminopeptidase 2 (Metap2) ELISA Kit

This competitive ELISA from Assay Genie is designed for the quantitative detection of mouse Methionine aminopeptidase 2 (MetAP2). Also referred to by synonyms including Initiation factor 2-associated 67 kDa glycoprotein, Peptidase M 2, p67eIF2, p67, MAP 2, MetAP 2, Mnpep, and P67eif2, the kit is reactive with mouse samples and accepts serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids.

Performance specifications include a detection range of 0.78-50ng/mL, a sensitivity of 0.39ng/mL, an intra-assay CV of 4.3%, and an inter-assay CV of 6.5%. The kit shows specificity for natural and recombinant mouse Methionine aminopeptidase 2 and is intended for research use only, within the epigenetics research area (UniProt: O08663).

MetAP2 is an enzyme involved in protein processing and regulation, contributing to cellular functions such as protein synthesis and degradation. The protein protects the eIF-2 alpha-subunit from inhibitory phosphorylation by eIF-2 kinases, plays a critical role in the regulation of protein synthesis, and interacts with the eIF-2 gamma-subunit. Dysregulation of MetAP2 has been linked to various diseases, including cancer and metabolic disorders, making it a valuable biomarker for studying these conditions and developing potential treatments.