Mouse Metalloproteinase inhibitor 3 (Timp3) ELISA Kit

A Sandwich ELISA from Assay Genie for measuring mouse Metalloproteinase inhibitor 3 (TIMP3) in serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids. The assay is specific for natural and recombinant mouse Metalloproteinase inhibitor 3 and is intended for research use only.

The kit has a detection range of 0.156-10ng/mL and a sensitivity of 0.089ng/mL. TIMP3 is described as a key regulator of metalloproteinases, playing a critical role in extracellular matrix remodeling, tissue repair, and inflammation. The protein complexes with metalloproteinases such as collagenases and irreversibly inactivates them by binding to their catalytic zinc cofactor, and may form part of a tissue-specific acute response to remodeling stimuli. Dysregulation of TIMP3 has been implicated in cancer, cardiovascular disorders, and inflammatory conditions.

The target is catalogued under UniProt P39876, with NCBI Gene ID 21859 and official symbol Timp3. The protein is secreted, located in the extracellular space and extracellular matrix, and interacts with EFEMP1. The associated research area is cancer.