Mouse Lrp2 (Low-density lipoprotein receptor-related protein 2) ELISA Kit (MOFI01407)

Quantitative measurement of mouse Low-density lipoprotein receptor-related protein 2 (megalin) is enabled by this Assay Genie ELISA Kit. Lrp2 is a large multiligand endocytic receptor that mediates uptake of lipoproteins, vitamin carriers, hormones, and toxins across polarized epithelia, with prominent expression in renal proximal tubules, choroid plexus, and thyroid follicles. In mouse models of kidney injury, megalin ectodomain shedding increases substantially, making circulating megalin fragments informative indicators of proximal tubular dysfunction. The kit accommodates a full microplate run and includes calibrated standards, detection antibody, and substrate solution for an absorbance-based readout on a standard plate reader. Researchers in nephrology, neuroscience, and toxicology use this reagent to investigate diabetic nephropathy, heavy-metal-induced tubulopathy, and blood-cerebrospinal fluid barrier integrity. Reagents should be stored refrigerated according to the instructions in the product insert, and the kit is intended for research use only.