Mouse Keratin, type I cytoskeletal 18 (Krt18) ELISA Kit

Assay Genie provides a Sandwich ELISA Kit designed for the accurate measurement of mouse Keratin, type I cytoskeletal 18 (KRT18) in mouse samples. The kit is validated for serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, and detects both natural and recombinant mouse KRT18 with a detection range of 0.78-50ng/mL and a sensitivity of 0.39ng/mL. Reported precision includes an intra-assay CV of 7.9% and an inter-assay CV of 9.6%.

KRT18 is a key cytoskeletal protein that helps maintain the structural integrity of epithelial cells, and its dysregulation has been linked to cancer and liver diseases, making it a valuable biomarker. Listed synonyms include Cytokeratin endo B, Cytokeratin-18, Keratin-18, Keratin D, CK-18, K18, Kerd and Krt1-18. When phosphorylated, the protein contributes to filament reorganization, the delivery of mutated CFTR to the plasma membrane, and the uptake of thrombin-antithrombin complexes by hepatic cells; together with KRT8, it is also involved in interleukin-6 (IL-6)-mediated barrier protection. Reported molecular weight values are 43 and 48 kDa, and subcellular localisation spans the nucleus matrix, nucleus, nucleolus and cytoplasm. For research use only.