Mouse Interleukin 22 Receptor Alpha 2 (IL-22Ra2) ELISA Kit

Interleukin-22 binding protein (IL-22BP), the soluble receptor also known as IL-22Ra2, antagonizes IL-22 signaling and modulates epithelial barrier integrity, mucosal immunity, and inflammatory responses in mouse models. The Assay Genie mouse IL-22Ra2 ELISA kit enables quantitative measurement of this decoy receptor in research samples, supplied as a 96-assay microplate kit for laboratory research use only.

IL-22Ra2 binds IL-22 with markedly higher affinity than the membrane-bound IL-22R1, acting as a natural brake on IL-22/STAT3 signaling in tissues such as the gut, skin, liver, and lung. Researchers apply this ELISA to investigate how IL-22BP expression shifts during colitis, psoriasis-like dermatitis, hepatitis, allergic airway inflammation, and bacterial or viral infection, and to probe regulatory feedback loops in Th17 and Th22 cell pathways.

Reagents are supplied as a complete kit including a pre-coated plate, detection antibody, standards, and assay buffers. Standard curve generation and sample handling follow the protocol insert, with absorbance read on a standard microplate reader. Component storage conditions and shelf life details are listed in the product datasheet; unopened kits are refrigerated until first use. The kit is intended for research use only and is not approved for clinical diagnostic procedures.