Mouse Integrator complex subunit 3 (Ints3) ELISA Kit

From Assay Genie, this Sandwich ELISA Kit is designed for the accurate quantification of Mouse Integrator complex subunit 3 (Ints3) in mouse serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The kit reacts specifically with mouse Integrator complex subunit 3, including both natural and recombinant forms, and provides a detection range of 78-5000pg/mL with a sensitivity of 39pg/mL.

INTS3 is a key component of the SOSS complex, a multiprotein assembly that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Dysregulation of INTS3 has been linked to various diseases, including cancer, neurodevelopmental disorders, and autoimmune diseases, making this kit a useful tool for investigating the molecular mechanisms of disease and developing novel treatments.

For research use only. The target protein localises to the nucleus and accumulates at nuclear foci following DNA damage, and is associated with UniProt entry Q7TPD0.