Mouse Inositol monophosphatase 1 (Impa1) ELISA Kit

This Sandwich ELISA from Assay Genie is designed for the accurate quantification of Inositol monophosphatase 1 (Impa1) levels in mouse serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The assay offers a detection range of 78-5000pg/mL with a sensitivity of 39.5pg/mL, and detects natural and recombinant mouse Inositol monophosphatase 1 with high specificity.

Impa1 is an enzyme involved in the phosphatidylinositol signaling pathway, where it plays a key role in cellular signal transduction and lipid metabolism. It is responsible for the provision of inositol required for the synthesis of phosphatidylinositol and polyphosphoinositides, and has been implicated as the pharmacological target for lithium action in the brain. Dysregulation of IMPA1 has been associated with mood disorders, bipolar disorder, and schizophrenia, making it a valuable target for research and drug development. The associated UniProt entry is O55023, with a reported molecular weight of 30,436 Da.

The enzyme functions as a homodimer located in the cytoplasm and exhibits broad substrate specificity, acting on myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP. The kit is intended for research use only and is suited to cardiovascular research applications.