Mouse HJV (Hemojuvelin) ELISA Kit (MOES01160)

Hemojuvelin, the bone morphogenetic protein co-receptor encoded by the Hfe2 gene, can be quantified in mouse experimental samples with this colorimetric ELISA kit from Assay Genie. The protein exists in both membrane-bound and soluble forms and acts through BMP6-driven signaling to regulate hepatic hepcidin expression and systemic iron homeostasis. Loss-of-function mutations in HJV underlie juvenile hemochromatosis in humans, and mouse strains carrying disrupted Hfe2 have become standard models for investigating iron overload, anemia of inflammation, and erythropoietic modulation of the hepcidin axis.

Supplied as a 96-assay kit, the product supports mid-throughput screening of tissue lysates and fluid samples from mouse experimental cohorts. Researchers studying BMP-SMAD signaling, hepcidin induction, or genetic modifiers of iron status can use this tool to track hemojuvelin levels across genotypes, dietary iron conditions, or pharmacological interventions. The assay follows a standard ELISA workflow and is compatible with plate readers commonly available in immunology and metabolism laboratories.

Typical applications include profiling hemojuvelin expression in liver, spleen, and serum compartments from mouse models, and validating gene expression findings at the protein level. Unopened kits should be refrigerated and protected from light until first use. The product is intended for research use only and is not validated for diagnostic or clinical decision-making.