Mouse Histone Deacetylase 4 (HDAC4) ELISA Kit

HDAC4 is a Class IIa deacetylase weighing roughly 140 kDa in mouse tissue, catalogued under UniProt accession Q6NZM9 with aliases HD4, HDAC-A and HDACA. The protein shuttles between the nucleus and cytoplasm, with phosphorylation at residues S246, S467 and S632 generating 14-3-3 binding motifs that anchor HDAC4 in the cytosol; CaMK, PKA, ERK1/2 and GSK3 drive this modification, while dephosphorylation frees the enzyme to enter the nucleus and repress MEF2-dependent transcription. Native expression is enriched in skeletal muscle, brain, heart and chondrocytes, where HDAC4 governs myocyte differentiation, chondrocyte hypertrophy and neuronal survival. Assay Genie supplies the kit with a 12 month shelf life when refrigerated, and reconstituted reagents tolerate a few freeze-thaw cycles before assay performance declines.