Mouse High Mobility Group Protein 1 (HMG1) ELISA Kit

Quantify HMGB1, a non-histone nuclear DNA-binding protein central to inflammation and damage signaling, in mouse research samples with this ELISA Kit from Assay Genie. When passively released from damaged or necrotic cells or actively secreted by activated immune cells, HMGB1 functions as a damage-associated molecular pattern (DAMP) and pro-inflammatory cytokine, mediating sepsis, sterile inflammation, autoimmune disease, traumatic injury, and tumor progression.

The 96-assay kit accommodates murine liquid and tissue-derived specimens in laboratory research settings, supporting studies that track systemic or local HMGB1 dynamics across disease models. Typical research applications include experimental sepsis, endotoxemia, collagen-induced arthritis, acute lung injury, and oncology investigations where HMGB1 release correlates with disease severity or therapeutic response. The microplate-based workflow integrates into standard immunology and inflammation pipelines, and is commonly combined with cytokine profiling and flow cytometry for comprehensive characterization of murine inflammatory cascades.