Mouse Glutamate--cysteine ligase catalytic subunit (Gclc) ELISA Kit

This Sandwich ELISA Kit from Assay Genie is designed for the quantitative detection of mouse Glutamate--cysteine ligase catalytic subunit (Gclc) in serum, plasma, tissue homogenates, cell culture supernates and other biological fluids [C0, S3].

Reported performance figures include a sensitivity of 0.44ng/mL and a detection range of 0.78-50ng/mL [S3]. The assay employs a colorimetric detection method [C0]. The kit is specific for natural and recombinant mouse Gclc and targets a heterodimer of a catalytic heavy chain and a regulatory light chain. Synonyms listed for the target include GCS heavy chain, Gamma-ECS, Gamma-glutamylcysteine synthetase, and Glclc [S3].

GCLC is a key enzyme in the synthesis of glutathione, an essential antioxidant that protects cells from oxidative stress and damage, supporting its value as a biomarker for studies of conditions such as aging, neurodegenerative diseases, and inflammatory disorders. The kit is for research use only and is suited to applications including cancer research [S3].