Mouse G Protein Beta 1 (GNb1) ELISA Kit

Applied in signal transduction and neurodevelopmental disease research, this microplate immunoassay kit from Assay Genie quantifies G protein subunit beta 1 (GNB1) levels in murine tissue homogenates. GNB1 is the conserved beta subunit of heterotrimeric G proteins, relaying signals from activated G-protein-coupled receptors to downstream effectors such as adenylyl cyclase, ion channels, and phospholipase C. Heterozygous missense mutations in GNB1 cause GNB1 encephalopathy, a neurodevelopmental syndrome characterized by intellectual disability, infantile seizures, hypotonia, and atypical movement patterns, so quantitative GNB1 protein assessment supports translational neuroscience and rare disease research programs.

Investigators probing GPCR desensitization mechanisms, neuronal migration, or cardiac beta-adrenergic signaling can deploy this kit to quantify GNB1 protein abundance. The microplate-based format supplies reagents for 96 assays per kit and is intended for in vitro research use only. Protocols are compatible with standard plate readers, and the assay is validated specifically for mouse reactivity. Not for diagnostic or therapeutic applications.