Mouse FUCA (Alpha-L-Fucosidase, Tissue) ELISA Kit (MOES01041)

Mouse models of lysosomal storage disease are central to fucosidosis research, and this Assay Genie ELISA kit provides quantitative measurement of tissue alpha-L-fucosidase (FUCA1) for studies in murine systems. The assay uses an absorbance-based readout in a microplate configuration, fitting standard plate-reader workflows in cell biology and immunology laboratories.

FUCA1 hydrolyzes terminal fucose residues on glycoproteins and glycolipids within the lysosome; deficiency causes progressive neurodegeneration, hepatosplenomegaly, and skeletal abnormalities in affected mice. Investigators can apply the kit to compare circulating enzyme levels in wild-type versus knockout cohorts, evaluate gene therapy interventions, or characterize enzyme modulators in compound screens.

The assay supports in vivo and in vitro experimental designs covering glycoprotein turnover, glycosphingolipid catabolism, and biomarker discovery for inherited metabolic disorders. By targeting the tissue-specific FUCA1 isozyme rather than the plasma form FUCA2, the panel enables specific interrogation of lysosomal enzyme activity in mouse models.