Mouse Fibroblast Growth Factor Receptor 3 (FGFR3) ELISA Kit

FGFR3 is a transmembrane receptor tyrosine kinase that regulates chondrocyte proliferation, skeletal elongation, and ossification during development. Gain-of-function mutations in FGFR3 cause achondroplasia and thanatophoric dysplasia, while somatic alterations drive oncogenic signaling in bladder carcinoma, multiple myeloma, and cervical cancer through constitutive activation of the RAS/MAPK and PI3K/AKT pathways.

This Assay Genie kit delivers a microplate-based quantitative immunoassay for measuring endogenous mouse FGFR3 protein in tissue homogenates, cell lysates, and related sample matrices. Each kit ships with a pre-coated plate, biotinylated detection antibody, lyophilized protein standards, streptavidin-HRP conjugate, wash concentrate, TMB substrate, and stop reagent.

Researchers commonly apply this reagent to study FGF ligand-receptor interactions involving FGF1, FGF2, FGF8, FGF9, and FGF18, to profile receptor overexpression in tumor xenograft lysates, and to characterize pharmacological FGFR inhibitors in vitro. Store unopened kit components refrigerated and protect from light; for research use only.