Mouse Extracellular calcium-sensing receptor (Casr) ELISA Kit

Assay Genie supplies a Sandwich ELISA Kit developed for the quantitative detection of mouse Extracellular calcium-sensing receptor (Casr). The colorimetric assay is intended for use with mouse-derived specimens including serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, and is presented by the manufacturer as a reliable tool for studying this G-protein coupled receptor that senses changes in extracellular calcium concentration.

According to the manufacturer, the assay works across a detection range of 78-5000pg/mL with a sensitivity of 39.7pg/mL. Specificity is reported for both natural and recombinant mouse Extracellular calcium-sensing receptor, and the kit is positioned for cardiovascular research applications. The target protein is a multi-pass membrane protein localised to the cell membrane, encoded by the gene Casr (NCBI Gene ID: 12374) and listed under UniProt accession Q9QY96, with a reported molecular weight of 111,996 Da. Listed synonyms include Parathyroid cell calcium-sensing receptor, PCaR1, CaSR, and Gprc2a.

CaSR is implicated in calcium homeostasis, parathyroid hormone secretion and bone metabolism, and its dysregulation has been linked to hyperparathyroidism, osteoporosis and kidney disease, supporting its use as a biomarker in studies of calcium signalling pathways and related disorders. The kit is labelled for research use only.