Mouse Endoribonuclease Dicer (Dicer1) ELISA Kit

This sandwich ELISA kit from Assay Genie is designed for the quantitative measurement of Endoribonuclease Dicer (DICER1), also known as double-strand-specific ribonuclease mDCR-1 and Mdcr, in mouse samples. Valid sample types include serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids. The assay uses a colorimetric detection method and shows specificity for natural and recombinant mouse Endoribonuclease Dicer.

DICER1 is a cytoplasmic type-III RNase that plays a central role in RNA interference pathways, producing the active small RNAs that repress gene expression. Along with Ago2 and TRBP, Dicer forms the main components of the RNA-induced silencing complex (RISC). Dysregulation of DICER1 has been implicated in various diseases, including cancer, autoimmune disorders, and neurological conditions, supporting its importance as a biomarker for disease research and therapeutic development.

The kit provides a detection range of 0.78-50 ng/mL with a sensitivity of 0.397 ng/mL. Intra-assay CV, inter-assay CV, linearity, and recovery data are provided with the kit. The target protein corresponds to UniProt entry Q8R418 and is localized to the cytoplasm. For research use only.