Mouse Disintegrin and metalloproteinase domain-containing protein 10 (Adam10) ELISA Kit

From Assay Genie, this Sandwich ELISA Kit is designed for the quantitative measurement of mouse Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10). It is reactive with mouse samples and is applicable across research areas including neurosciences, cell biology, immunology, and disease pathology. The kit detects natural and recombinant mouse ADAM10, with a detection range of 0.156-10ng/mL and a sensitivity of 0.081ng/mL.

ADAM10 is a key metalloproteinase involved in cell adhesion, migration, and signalling processes, with roles in development, immune response, and inflammation regulation. Dysregulation of ADAM10 has been implicated in conditions such as cancer, Alzheimer's disease, and inflammatory disorders, making it a valuable biomarker for studying these conditions. Functionally, ADAM10 acts as an alpha-secretase, responsible for the proteolytic release of several cell-surface proteins, including the cleavage of amyloid precursor protein (APP), TNF-alpha, ephrin-A2, CD44, CDH2, and Notch. The product is intended for research use only.

Acceptable sample types include serum, plasma, tissue homogenates, cell culture supernatants, and other biological fluids. Synonyms listed for the target include Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD156c, ADAM 10, Kuz, and Madm. The associated UniProt accession is O35598.