Mouse Dihydropyrimidine Dehydrogenase (DPYD) ELISA Kit

Quantitative measurement of mouse dihydropyrimidine dehydrogenase (DPYD) enzyme levels supports research into pyrimidine catabolism, fluoropyrimidine metabolism, and pharmacogenomic studies of chemotherapy response. This ELISA kit from Assay Genie is configured for use with tissue homogenates and cell lysate samples, processed on a standard microplate. DPYD catalyzes the NADPH-dependent reduction of uracil and thymine, the rate-limiting step in pyrimidine breakdown, and altered expression is linked to 5-fluorouracil toxicity, tumor metabolism, and inherited metabolic disorders. Investigators working with colorectal, gastric, and breast cancer mouse models employ this assay to correlate enzyme levels with drug sensitivity and resistance phenotypes. The kit supports in vitro enzymatic characterization and preclinical mouse model investigation, with reagents supplied for 96 determinations. For research use only, it provides a reproducible tool for screening biological replicates and treatment cohorts in cancer pharmacology studies.