Mouse Dihydropyrimidinase-related protein 3 (Dpysl3) ELISA Kit

A sandwich-format ELISA from Assay Genie, this kit enables quantitative measurement of dihydropyrimidinase-related protein 3 (DPYSL3) in mouse samples. The target, also known as collapsin response mediator protein 4 (CRMP4), regulates axonal growth and guidance and contributes to neurite outgrowth, neuronal migration, and synaptic plasticity; its dysregulation has been linked to neurodegenerative disorders.

The assay uses a colorimetric detection method and is validated for serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids, with specificity for natural and recombinant mouse dihydropyrimidinase-related protein 3. Quoted performance figures include a detection range of 31.2-2000 pg/mL and a sensitivity of 15.62 pg/mL. The associated UniProt accession is Q62188.

Functionally, DPYSL3 supports signaling by class 3 semaphorins and downstream cytoskeletal remodelling, playing roles in axon guidance, neuronal growth cone collapse, and cell migration. The protein forms homotetramers and heterotetramers with CRMP1, DPYSL2, DPYSL4, or DPYSL5 and interacts with synaptic vesicle protein 2 and the SH3A domain of intersectin; it localises to the cytoplasm, cell projections, and growth cones. For research use only.