Mouse D (2)dopamine receptor (Drd2) ELISA Kit

Manufactured by Assay Genie, this sandwich ELISA kit is designed for the quantitative measurement of mouse D(2) dopamine receptor (DRD2), also known as Dopamine D2 receptor. The assay detects natural and recombinant mouse D(2) dopamine receptor and is reactive with mouse samples, including serum, plasma, cell culture supernatants, tissue homogenates, and other biological fluids. Detection is colorimetric, and the kit is intended for research use only.

Reported performance characteristics include a detection range of 0.312–20 ng/mL and a sensitivity of 0.156 ng/mL. Intra-assay precision (CV) is 5.2% and inter-assay precision is 7.7%. Linearity has been assessed in serum, EDTA plasma, and heparin plasma across dilutions of 1:2 to 1:16, and recovery has been evaluated in serum (average 89%, range 83–95%) and plasma (average 91%, range 85–97%).

DRD2 is a G-protein coupled receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Dysregulation of DRD2 has been implicated in neurological and psychiatric disorders including Parkinson's disease, schizophrenia, and addiction, making it a relevant target within neuroscience research. UniProt reference: P61168; subcellular location: cell membrane, multi-pass membrane protein.