Mouse Cyclin-dependent kinase 5 (Cdk5) ELISA Kit

Manufactured by Assay Genie, this sandwich ELISA kit is designed for the quantitative detection of mouse Cyclin-dependent kinase 5 (Cdk5), with reactivity limited to mouse samples. The assay accommodates serum, plasma, tissue homogenates, cell culture supernates and other biological fluids, and operates on a colorimetric detection principle. Reported performance figures include a detection range of 0.156-10ng/mL and a sensitivity of 0.069ng/mL, with specificity for natural and recombinant mouse Cyclin-dependent-like kinase 5.

Targeted at the neurosciences research area, the kit supports work on CDK5, a proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest, differentiation and synaptic plasticity. As outlined by the manufacturer, CDK5 activity is heavily implicated in neuronal development and survival, and dysregulation of the kinase has been linked to neurodegenerative disorders including Alzheimer's and Parkinson's disease, making accurate measurement of CDK5 levels valuable for studies of disease mechanism and potential therapeutic targets.