Mouse Coagulation factor XIII A chain (F13a1) ELISA Kit

From Assay Genie, this Sandwich ELISA kit is designed for the quantitative detection of mouse Coagulation Factor XIII A chain (F13A1) in serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids. The kit specifically detects natural and recombinant mouse F13A1 with high sensitivity and specificity, making it suitable for a diverse range of research applications.

F13A1 plays a key role in the blood clotting process, where it stabilises blood clots by catalysing the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains. Factor XIII is activated by thrombin and calcium ion to function as a transglutaminase. Dysregulation of F13A1 has been implicated in various bleeding disorders and clotting abnormalities, making it an important biomarker for studying these conditions and potential therapeutic interventions. The native protein is a tetramer of two A chains (F13A1) and two B (F13B) chains (UniProt: Q8BH61), with synonyms including Protein-glutamine gamma-glutamyltransferase A chain, Transglutaminase A chain, Coagulation factor XIIIa, and F13a.

Performance specifications include a detection range of 0.78-50 ng/mL and a sensitivity of 0.447 ng/mL, using a colorimetric detection method. Intra-assay CV, inter-assay CV, linearity, and recovery data are provided as part of the kit documentation. For research use only.