Mouse Cereblon (CRBN) ELISA Kit

Quantitative measurement of cereblon (CRBN) protein in mouse research samples is supported by this enzyme-linked immunosorbent assay from Assay Genie. Cereblon operates as the substrate recognition component of the CRL4 E3 ubiquitin ligase complex (CUL4-DDB1-CRBN), placing it at the centre of studies on thalidomide-class pharmacology and IMiD-based therapeutics development in multiple myeloma and related disease models.

Configured for 96 assays with a colorimetric readout compatible with standard microplate readers, the kit is validated for mouse species reactivity and accepts tissue homogenates as the primary sample input. It fits into workflows where specimens from preclinical mouse studies are profiled for CRBN expression under different genetic backgrounds or pharmacological perturbations, including investigations of cereblon-mediated neo-substrate recruitment and downstream ubiquitin-dependent protein degradation.

Beyond oncology applications, the kit is relevant to neuroscience research where autosomal recessive mutations in CRBN have been linked to intellectual disability phenotypes. All reagents should be refrigerated on receipt and equilibrated to working temperature before the assay is initiated.