Mouse Bile acid receptor (Nr1h4) ELISA Kit

A sandwich ELISA from Assay Genie is designed for the quantitative measurement of mouse bile acid receptor NR1H4, also known as the farnesoid X receptor (FXR). The kit uses a colorimetric detection method and is intended for research use only.

NR1H4 is a ligand-activated transcription factor that plays a key role in bile acid homeostasis and lipid metabolism, and its dysregulation has been linked to liver diseases, metabolic disorders, and inflammatory conditions, making it an important target for biomarker and therapeutic research. The kit detects natural and recombinant mouse Bile acid receptor, with a detection range of 78-5000 pg/mL and a sensitivity of 40 pg/mL. It is validated for use with serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids.

The target is localised to the nucleus and binds DNA predominantly as a heterodimer with RXRA (UniProt Q60641, NCBI Gene ID 20186), with isoform 4 reported to activate transcription of IBAP and SDC1. Reactivity is specified for mouse samples, exact storage details are provided with the kit components, and the listed research area is cardiovascular. Recorded synonyms include Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, Bar, Fxr, and Rip14.