Mouse B-cell lymphoma/leukemia 11B (Bcl11b) ELISA Kit

Assay Genie supplies a sandwich ELISA kit designed for the quantitative measurement of B-cell lymphoma/leukemia 11B (Bcl11b) in mouse samples. The kit is intended for research use only and supports studies of hematological malignancies and immune system disorders in mouse models, as dysregulation of BCL11B expression has been linked to various lymphoma and leukemia subtypes.

Performance characteristics include a detection range of 78-5000pg/mL and a sensitivity of 39pg/mL. Intra-assay CV is reported at 6.4% and inter-assay CV at 9.1%. Recovery in serum averages 95% (range 89-101%) and in plasma averages 97% (range 91-103%). The assay shows specificity for natural and recombinant mouse B-cell lymphoma/leukemia 11B.

Validated sample types include serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids. Bcl11b (UniProt Q99PV8) is described as a tumor-suppressor protein involved in T-cell lymphomas and a key regulator of differentiation and survival during thymocyte development, with a nuclear subcellular location.