Mouse Asporin (Aspn) ELISA Kit

Manufactured by Assay Genie, this colorimetric Sandwich ELISA Kit is intended for the quantitative detection of asporin in mouse samples, with stated reactivity for serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. The kit is supplied for research use only.

Performance characteristics reported by the manufacturer include a detection range of 1.56-100ng/mL and a sensitivity of 0.802ng/mL. Specificity is stated for natural and recombinant mouse asporin. Asporin is described as a small leucine-rich proteoglycan and an extracellular matrix protein that binds calcium and contributes to osteoblast-driven collagen biomineralization. It acts as a critical regulator of TGF-beta in articular cartilage, with roles in cartilage homeostasis and osteoarthritis pathogenesis, and negatively regulates periodontal ligament differentiation and mineralization.

The associated research area is metabolism, and asporin is localised to the extracellular space and extracellular matrix as a secreted factor. The protein is also known by the synonyms Periodontal ligament-associated protein 1 (PLAP-1).