Mouse Amyloid Beta Peptide 1-40 (Ab1-40) ELISA Kit

Amyloid beta peptide 1-40 (Aβ1-40) is a 40-amino acid proteolytic fragment generated from amyloid precursor protein through sequential β- and γ-secretase cleavage, and it accumulates alongside the more aggregation-prone Aβ1-42 species in the brains of Alzheimer's disease models. This Assay Genie competitive immunoassay is calibrated against the murine form of the peptide, which differs from human Aβ1-40 at three residues (R5G, Y10F, H13R), making it useful for studies using transgenic mouse lines such as APPswe/PS1dE9, 5xFAD, and 3xTg-AD that recapitulate plaque pathology. Researchers commonly apply the kit to brain homogenate supernatants, cerebrospinal fluid, and peripheral blood to monitor peptide levels across disease progression, during pharmacological intervention, or following environmental and dietary manipulations. The competitive format is particularly suited to short peptide targets that present only a single epitope, allowing detection without requiring a matched antibody pair.