Mouse A disintegrin and metalloproteinase with thrombospondin motifs 4 (Adamts4) ELISA Kit

From Assay Genie, this Sandwich ELISA kit is intended for the quantitative detection of mouse A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), also referred to as Aggrecanase-1 or ADAM-TS 4. The assay uses a colorimetric detection method and is described as a highly accurate and reliable tool that delivers precise and reproducible results, suited to research into cartilage degradation, osteoarthritis and inflammation.

Quoted performance figures include a detection range of 0.625-40ng/mL and a sensitivity of 0.335ng/mL. The kit is reactive with mouse samples and accepts serum, plasma, tissue homogenates, cell culture supernates and other biological fluids. Specificity covers both natural and recombinant mouse ADAMTS4. ADAMTS4 is a secreted protein found in the extracellular space and matrix that cleaves the cartilage proteoglycan aggrecan at the '392-Glu-|-Ala-393' site and has been implicated in aggrecan turnover and destruction in arthritic diseases. The associated UniProt entry is Q8BNJ2 and the listed research area is Cell Biology.

For research use only. Components and additional reagents require storage at -20°C and 4°C; please refer to the kit documentation for exact storage details. Required equipment not supplied includes a microplate reader with a 450 nm filter, multichannel pipette, incubator and deionised or distilled water.