Human XRCC4 (DNA repair protein XRCC4) ELISA Kit (HUFI05637)

XRCC4 is a critical scaffolding protein in the canonical non-homologous end joining (NHEJ) DNA double-strand break repair pathway, where it partners with DNA Ligase IV and the Ku70/Ku80 heterodimer to reseal breaks generated during V(D)J recombination, class-switch recombination, and exposure to ionizing radiation or chemotherapeutic agents. The Human XRCC4 ELISA Kit from Assay Genie measures XRCC4 protein concentrations in human donor samples through an immunoassay format validated for serum separator tube fractions and EDTA-plasma aliquots, supporting direct integration into clinical research biobank workflows.

Quantifying circulating XRCC4 levels aids research programs in DNA damage response, radiosensitivity profiling, genomic instability in tumor biology, and biomarker discovery across oncology, immunology, and radiation biology. Each kit provides reagents for 96 individual assay runs read on a standard microplate absorbance reader, with components supplied ready-to-use in labeled vials. Store refrigerated; protect from light. Aliquot the reconstituted standard and detection antibody to limit freeze-thaw cycles and preserve immunoreactivity. For research use only; not validated or licensed for clinical diagnostic procedures.