Human WNK4 ELISA Kit (HUFI05639)

Quantitative measurement of human WNK4 (With No Lysine Kinase 4) is supported by this ELISA Kit from Assay Genie, formatted for 96 Assays. WNK4 is a serine/threonine kinase expressed predominantly in the kidney distal convoluted tubule and collecting duct, where it regulates the thiazide-sensitive sodium-chloride cotransporter (NCC) and several other ion transporters through a kinase-independent scaffold mechanism.

The kit supports research into pseudohypoaldosteronism type II (Gordon syndrome), a Mendelian hypertension disorder caused by gain-of-function mutations in the WNK4 gene that produce hyperkalemia, metabolic acidosis, and elevated blood pressure. It is also relevant to studies of renal salt handling, NCC modulation, and the broader WNK-SPAK/OSR1 kinase signaling cascade.

Provided with absorbance-based readout on a standard microplate reader, the assay fits standard ELISA workflows in laboratory research settings. WNK4 is a 1,243-amino-acid kinase whose abundance and regulation are investigated in connection with electrolyte homeostasis and hypertensive disease mechanisms.