Human WDR45 ELISA Kit (HUFI05661)

Quantify WD Repeat Domain 45 (WDR45) in human specimens with this quantitative immunoassay from Assay Genie, which produces a colorimetric signal measurable on a standard plate reader. WDR45 is a cytoplasmic scaffolding protein of approximately 40 kDa that anchors the ATG2A-WIPI4 lipid transfer complex at the phagophore, driving autophagosome expansion; loss-of-function mutations in the X-linked WDR45 gene cause Beta-Propeller Protein-Associated Neurodegeneration (BPAN), a juvenile-onset NBIA subtype characterized by static encephalopathy in childhood followed by progressive dystonia-parkinsonism in early adulthood. Laboratories investigating autophagy flux, ferroptosis crosstalk, and lysosomal homeostasis measure WDR45 abundance in patient lymphoblasts, induced pluripotent stem cell-derived neurons, and matched serum or plasma specimens to map genotype-phenotype correlations and to screen candidate therapeutics in vitro. The microplate delivers 96 Assays per box, sufficient for full standard curves plus sample replicates across multiple experimental cohorts. Reconstituted standards and biotinylated detection antibody remain stable through the kit's shelf life when stored refrigerated and protected from light, while the wash concentrate tolerates room temperature handling during extended runs. For research use only, not for clinical diagnostic decision making.