Human Von Hippel Lindau Tumor Suppressor (vHL) ELISA Kit

This quantitative immunoassay from Assay Genie enables sensitive measurement of the Von Hippel-Lindau tumor suppressor protein in human research samples. VHL functions as the substrate recognition component of an E3 ubiquitin ligase complex that targets hypoxia-inducible factors for proteasomal degradation, making accurate protein quantification valuable for studies of clear-cell renal cell carcinoma, hemangioblastoma development, pheochromocytoma biology, and hereditary VHL disease mechanisms.

Investigators can profile VHL protein across diverse matrices including serum specimens, plasma specimens, tissue homogenates, cell lysates, and conditioned cell culture media. Each kit supplies reagents and pre-coated microplate wells sufficient for 96 determinations, and the method is validated for research use only. Reagents should be stored refrigerated upon arrival, and the protocol supports standard curve generation, intra-assay precision assessment, and parallel processing of experimental alongside control samples. Applications include pathway dysregulation analysis, hypoxia response investigation, and therapeutic target validation in relevant in vitro cellular systems and in vivo animal models of renal carcinoma.