Human V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) ELISA Kit

RELB functions as the transactivating partner of p52/p100, dimerizing to translocate into the nucleus and activate transcription of genes regulating chemokine secretion, lymphoid tissue architecture, and survival of B-lymphocyte subsets. Loss-of-function studies in murine models link RELB deficiency to thymic atrophy, absent germinal centres, and disrupted splenic organisation, underscoring the relevance of quantitative RELB measurement when modelling autoimmune, oncogenic, or chronic inflammatory phenotypes in vitro.

The human-specific capture and detection antibodies in this Assay Genie kit are paired against recombinant RELB reference material, and each lot is validated for intra-assay precision before release. Researchers tracking NIK-IKKα-p100 axis activity, comparing RELB expression between tumour and matched normal tissue, or screening compounds that modulate alternative NF-κB signalling can incorporate the assay alongside western blot verification of p52 processing to strengthen their datasets.