Human USP22 ELISA Kit (HUFI05770)

USP22 (Ubiquitin-Specific Peptidase 22) is a critical deubiquitinating enzyme that functions as the catalytic subunit of the SAGA (Spt-Ada-Gcn5 Acetyltransferase) transcriptional coactivator complex. This histone H2B deubiquitinase plays essential roles in chromatin remodeling, transcriptional elongation, and cell cycle progression.

Research interest in USP22 has grown substantially because it was identified among the "death-from-cancer" signature genes, with elevated expression linked to tumor aggressiveness and poor prognosis across multiple cancer types, including colorectal, breast, lung, and prostate malignancies. USP22 also regulates DNA damage response pathways, autophagy, and metabolic reprogramming, making it a focal target in studies of the ubiquitin-proteasome system.

This quantitative immunoassay kit from Assay Genie enables researchers to measure USP22 protein levels in research specimens, supporting investigations into cancer biology, signal transduction, and epigenetic regulation. The 96 Assays platform provides throughput suited to cohort studies and biomarker validation experiments. Intended for research use only in laboratory settings, not for diagnostic procedures.