Human UNC13D/Munc13-4 ELISA Kit (HUFI05792)

Researchers investigating familial hemophagocytic lymphohistiocytosis, NK-cell cytotoxicity, or vesicle-priming pathways use the Assay Genie Human UNC13D/Munc13-4 ELISA Kit to quantify Munc13-4 protein levels in human specimens. Munc13-4 is the product of the UNC13D gene and is required for the priming step of cytotoxic granule release in natural killer cells and CD8+ T lymphocytes; biallelic loss-of-function mutations in UNC13D are the established molecular basis of familial hemophagocytic lymphohistiocytosis type 3, a life-threatening hyperinflammatory syndrome of infancy and early childhood. The assay is configured as a complete research-use-only kit and follows standard microplate-based ELISA methodology, producing a measurable signal proportional to Munc13-4 abundance in each loaded well. All reagents required for the run are supplied in vials, and the kit is intended to support studies in immunology, hematology, hyperinflammation, and primary immunodeficiency research, where Munc13-4 protein levels are being evaluated as a biomarker of cytotoxic granule function.