Human Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) ELISA Kit

A sandwich ELISA kit from Assay Genie for the quantitative detection of human Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also referred to as Transmembrane activator and CAML interactor, CD267 and TACI. The assay is intended for use with human samples including serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids, and shows specificity for natural and recombinant human TNFRSF13B.

Reported performance characteristics include a detection range of 0.312–20 ng/mL and a sensitivity of 0.12 ng/mL. Intra-assay precision is listed at 4.8% (Intra CV) and inter-assay precision at 8.1% (Inter CV). Recovery in serum averages 99% (range 93–105%) and in plasma averages 101% (range 95–107%). The target is annotated as a single-pass type III membrane protein, the listed research area is Cancer, and the kit is for research use only.

TNFRSF13B functions as a receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS, binding both ligands with similar high affinity, and mediates calcineurin-dependent activation of NF-AT as well as activation of NF-kappa-B and AP-1. It is involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.