Human TSEN2 ELISA Kit (HUFI05923)

TSEN2 (tRNA splicing endonuclease subunit 2) functions as a catalytic component of the tRNA-splicing endonuclease complex responsible for cleaving introns from precursor tRNAs during maturation. Loss-of-function mutations in TSEN2 cause Pontocerebellar Hypoplasia type 2B (PCH2B), a severe neurodevelopmental disorder characterized by progressive cerebellar and brainstem atrophy. The Assay Genie kit supports quantitative measurement of TSEN2 protein levels, making it applicable for researchers studying tRNA biology, neurodegeneration, or rare neurological disease mechanisms. Each kit includes a pre-coated microplate requiring 100 uL of sample per well, with absorbance-based readout suitable for high-throughput laboratory workflows. Reagents should be stored refrigerated at 4°C and protected from light, with reconstituted standards aliquoted to limit freeze-thaw cycles. For research use only; not validated for diagnostic applications.