Human Tripeptidyl-peptidase I/TPP1 PharmaGenie ELISA Kit (SBRS1176)

TPP1 (Tripeptidyl-peptidase I), also known as CLN2, is a lysosomal serine protease that cleaves tripeptides from the N-terminus of polypeptides; its deficiency is the genetic cause of late infantile neuronal ceroid lipofuscinosis (CLN2 disease), making quantitative measurement of this enzyme valuable for lysosomal storage disorder research, neurodegeneration biomarker discovery, and patient-derived sample profiling. The Assay Genie PharmaGenie kit uses recombinant antibody pairs in an absorbance-based ELISA format to quantify endogenous TPP1 from human cell culture supernatant, plasma, and serum starting material. Each kit supplies reagents for 96 assays and is intended for research use only, supporting work such as monitoring TPP1 expression in disease models, validating compounds that modulate enzyme activity, and screening samples from CLN2-relevant studies. Components typically include pre-coated microplate wells, recombinant calibrator, biotinylated detection antibody, streptavidin-HRP conjugate, wash buffer, substrate solution, and stop solution; consult the lot-specific insert for component volumes, storage conditions, and the recommended assay workflow.