Human TREX1 (Three-prime repair exonuclease 1) ELISA Kit (HUFI05962)

Quantitative measurement of Three-prime repair exonuclease 1 (TREX1) in human research samples is supported by the dedicated Assay Genie kit. TREX1 is the major cytosolic DNA exonuclease in mammalian cells, responsible for degrading single-stranded DNA and DNA/RNA hybrids to prevent the cytosolic accumulation of nucleic acid by-products that would otherwise trigger aberrant innate immune activation via cGAS-STING and related pathways. Researchers investigating type I interferonopathies, Aicardi-Goutières syndrome, familial chilblain lupus, and systemic lupus erythematosus use the kit to assess TREX1 protein abundance in clinical specimens. The ELISA workflow delivers an absorbance-based readout suitable for in vitro research use only, with reagents and plates supplied for 96 Assays. Components should be refrigerated on arrival and handled according to the kit insert. The format supports parallel processing of patient-derived samples for biomarker and pathway studies, providing a useful resource for projects aimed at understanding TREX1 dysfunction in autoimmune and neuroinflammatory disease contexts.