Human TREM-2 PharmaGenie ELISA Kit (SBRS1188)

Quantify Triggering Receptor Expressed on Myeloid cells 2 (TREM-2) in human research samples with the Human TREM-2 PharmaGenie ELISA Kit from Assay Genie. TREM-2 is a single-pass transmembrane receptor expressed primarily on microglia, macrophages, and other myeloid lineage cells, where it regulates phagocytosis, inflammatory signaling, and survival of innate immune cells in the central nervous system. Soluble TREM-2 fragments generated by proteolytic cleavage have attracted considerable interest as biomarkers reflecting microglial activation and neurodegeneration.

This immunoassay is intended for research use only and supports studies investigating Alzheimer's disease, frontotemporal dementia, amyotrophic lateral sclerosis, and Nasu-Hakola disease, where loss-of-function variants in TREM2 alter risk and progression. Compatible sample types include cell culture supernatants, plasma, and serum. Each kit contains reagents for one microplate and should be stored refrigerated between uses. The assay readout integrates with standard laboratory plate readers, allowing laboratories to obtain quantitative measurements without specialized instrumentation.

Applications include profiling soluble TREM-2 in patient cohorts, monitoring microglial responses in cell culture models, and screening compounds that modulate TREM-2 signaling pathways. Researchers studying neurodegeneration, neuroinflammation, and innate immunity will find this kit useful for both targeted biomarker studies and broader pathway analyses.