Human Transferrin receptor protein 2 (TFR2) ELISA Kit

From Assay Genie, this Sandwich ELISA kit is designed for the quantitative measurement of human Transferrin Receptor Protein 2 (TFR2), a single-pass type II membrane protein that mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner and is implicated in iron metabolism, hepatocyte function, and erythrocyte differentiation. The kit is intended for research use only and is reactive with human samples.

The assay reports a detection range of 0.156-10ug/mL and a sensitivity of 0.078ug/mL, with intra-assay CV of 3.9% and inter-assay CV of 7.2%. Validated sample types include serum, plasma, tissue homogenates, cell culture supernates, and other biological fluids, with specificity demonstrated for natural and recombinant human TFR2. The target protein functions as a homodimer (UniProt Q9UP52).

TFR2 is a key regulator of iron homeostasis, and defects in the protein are a cause of hemochromatosis type 3 (HFE3), a disorder characterized by iron overload and complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. By enabling precise quantification of TFR2 levels, the kit supports research into iron metabolism, hereditary hemochromatosis, and related disorders, with the listed research area being cardiovascular.