Human Topoisomerase II Beta (TOP2b) ELISA Kit

Topoisomerase II Beta is a nuclear enzyme that resolves DNA supercoiling and catenation by generating transient double-strand breaks and religating the DNA backbone. Quantitative measurement of TOP2B supports research into transcription regulation, chromatin remodeling, mitotic chromosome segregation, and cellular responses to topoisomerase-targeting agents such as etoposide and doxorubicin. Altered TOP2B expression has been examined in neurodevelopment, neurodegenerative disease models, and in tumor tissues where it can influence sensitivity to chemotherapy.

The Assay Genie Human Topoisomerase II Beta (TOP2b) ELISA Kit provides a quantitative ELISA for measuring TOP2B in human tissue homogenates and related sample matrices, producing an absorbance-based readout on a standard microplate. The microplate format supports research use only workflows in molecular biology, pharmacology, and oncology laboratories studying DNA topology, chromosome dynamics, and genotoxic stress response pathways.