Human TOP3A ELISA Kit (HUFI06015)

DNA topoisomerase III alpha (TOP3A) is a type IA topoisomerase that resolves topological stress during replication, recombination, and repair. It partners with BLM helicase within the BTRR complex to dissolve double Holliday junctions, a function central to maintaining genomic stability. This Assay Genie kit provides a quantitative immunoassay for measuring TOP3A protein levels in human samples, supporting research into Bloom syndrome biology, DNA repair mechanisms, and cancer pathways where TOP3A expression is frequently altered.

The 96 Assays format with colorimetric read-out integrates into laboratory workflows investigating topoisomerase function, including studies of mitochondrial DNA maintenance where TOP3A also contributes to genome integrity. Researchers can apply the kit to characterize protein abundance in clinical cohorts and experimental models. Marketed for research use only, the assay enables investigation of how TOP3A dysregulation influences cellular responses to DNA damage and contributes to disease phenotypes.