Human TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A) CLIA Kit (HUES00176)

The Tumor Necrosis Factor Receptor Superfamily Member 1A (TNFRSF1A), also known as TNFR1, p55, or CD120a, is a 55 kDa transmembrane receptor that binds TNF-alpha with high affinity. It drives downstream signaling cascades including NF-kappaB activation and caspase-mediated apoptosis, and dysregulated TNFR1 activity is implicated in rheumatoid arthritis, Crohn's disease, ulcerative colitis, septic shock, multiple sclerosis, and the autoinflammatory condition TRAPS. Quantifying soluble TNFRSF1A therefore serves as a valuable biomarker across immunology, inflammation, and oncology research workflows.

Chemiluminescent detection from Assay Genie offers an extended dynamic range and lower detection threshold than colorimetric alternatives, supporting accurate measurement of low-abundance receptor levels in experimental samples. The microplate-format kit is validated for in vitro research use on human specimens. Unopened components should be stored refrigerated; reconstituted reagents are typically aliquoted and held frozen to preserve activity across repeated freeze-thaw cycles.