Human TMPRSS6 (Transmembrane protease serine 6) ELISA Kit (HUFI04765)

Targeting a central regulator of iron homeostasis, this Assay Genie ELISA enables quantitative measurement of human transmembrane protease serine 6 (TMPRSS6), also called matriptase-2, in research samples. TMPRSS6 is a type II transmembrane serine protease expressed predominantly in hepatocytes, where it suppresses hepatic hepcidin production and therefore controls systemic iron availability. Loss-of-function variants in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA), while altered activity has been reported in anemia of chronic disease, hereditary hemochromatosis, and certain inflammatory states.

Supplied as a complete 96 Assays format kit, the assay supports investigations of the protease–hepcidin axis, including how circulating TMPRSS6 concentrations relate to BMP–SMAD signaling, ferroportin turnover, and erythropoietic drive. It is relevant to hematology research, hepatic iron handling studies, and chronic kidney disease, and it pairs with cell culture and in vivo models that probe how inflammation, dietary iron, or supplementation reshape TMPRSS6 expression.

The kit includes all reagents needed to process a full microplate. Researchers are advised to handle components according to the supplied protocol, prepare aliquots to limit freeze-thaw cycles, and treat the assay strictly as research use only. Assay Genie provides technical documentation with each shipment to support standard curve generation, sample dilution planning, and data interpretation.