Human TLL1 (Tolloid-like protein 1) ELISA KIT (HUFI04822)

Quantitative measurement of human Tolloid-like protein 1 supports research into extracellular matrix remodeling, hepatic fibrogenesis, and lipid metabolism. The Assay Genie TLL1 ELISA Kit is a 96 Assays plate-based immunoassay built to detect circulating protein in human blood-derived samples.

TLL1 is a zinc-dependent astacin-like metalloprotease that cleaves procollagen C-propeptide, chordin, BMP-1 substrates, and sclerostin, placing it at the intersection of connective tissue turnover, bone formation, and cardiac septation during development. In adult biology, elevated hepatic TLL1 expression tracks with collagen deposition in chronic liver disease, and a non-coding variant at the TLL1 locus (rs3812944) has been linked to reduced LDL cholesterol and lower coronary artery disease risk across multiple cohorts. Researchers investigating liver fibrosis staging, ECM remodeling, or dyslipidemia use this kit to quantify protein levels and correlate findings with histology, imaging, or genotype data.

Each kit is supplied in a 96 Assays configuration with the pre-coated plate, detection reagents, reference standards, and assay buffers needed to build a standard curve and read unknowns. The plate-based colorimetric workflow integrates with standard microplate readers used in immunology and biomarker laboratories. Reagents should be refrigerated between uses to preserve activity across runs, and the kit is for in vitro research use only.