Human Tissue Factor (TF) ELISA Kit

Tissue Factor (TF), a 47 kDa transmembrane glycoprotein that initiates the extrinsic blood coagulation cascade, can be quantified in human plasma using the Assay Genie ELISA kit, configured for 96 individual determinations per microplate.

Also known as Factor III, thromboplastin, or CD142, Tissue Factor binds plasma Factor VIIa to trigger downstream thrombin generation and fibrin formation. Beyond classical hemostasis, aberrant TF expression has been linked to tumor metastasis, angiogenesis, sepsis-associated coagulopathy, atherothrombosis, and inflammatory signaling, making circulating TF antigen a relevant readout for translational studies across cardiovascular, oncology, and critical-care research laboratories.

The microplate-based assay is calibrated for use with human plasma specimens and is intended for research use only. Typical applications include profiling TF upregulation in cancer cell lines and tumor xenograft models, evaluating procoagulant activity in models of sepsis and disseminated intravascular coagulation, and biomarker validation in clinical cohorts examining endothelial dysfunction and thrombotic risk.