Human TFAP2A/AP-2 ELISA Kit (HUFI06136)

TFAP2A encodes the AP-2α transcription factor, a 52 kDa DNA-binding protein that recognizes GCC-N3-GGC motifs and regulates target gene expression during neural crest cell migration, craniofacial morphogenesis, and ectodermal differentiation. Research interest in this gene spans developmental biology, where heterozygous loss-of-function mutations underlie branchio-oculofacial syndrome, and oncology, where elevated AP-2α expression has been documented in melanoma, triple-negative breast carcinoma, oral squamous cell lesions, and Wilms tumor, influencing proliferation, epithelial-mesenchymal transition, and chemotherapeutic response.

Researchers apply this ELISA reagent set to quantify AP-2α levels in patient-derived samples, supporting biomarker discovery studies in cancer cohorts and investigations of developmental signaling pathways. The kit is supplied by Assay Genie in a 96 Assays microplate format, has been validated for detection of human AP-2α in cell lysate and tissue homogenate samples, and is intended for research use only.